Plenty of recent research has shown compelling correlations between gut microbiome alterations and mood disorders such as depression. But exactly how bacteria in the gut could be influencing depressive behaviors has been unclear. New research from a team of French scientists is shedding light on one possible causal mechanism, describing a pathway by which changes to the microbiome results in decreased activity in the hippocampus and subsequent depressive behavior.
The new research began by investigating microbiome changes in a mouse model of stress-induced depression. As well as initially examining the microbiome differences between healthy animals and animals with mood disorders, the researchers discovered those mood disorders could be transferred to the healthy animals via fecal transplants.
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